Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4.
نویسندگان
چکیده
A helical tyrosine-sulfated epitope in CCR5 that is recognized by the human immunodeficiency virus type-1 envelope glycoprotein gp120 in its CD4-induced conformation can be mimicked structurally by a cyclic β-hairpin peptide containing two sulfated tyrosine residues at positions i and i + 2 along one β-strand.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 41 شماره
صفحات -
تاریخ انتشار 2010